This reference describes the chemistry of organocalcium compounds that contain a Ca-C σ-bond. It collects the information about this niche group of organometallic compounds into 4 easy-to-read chapters. It is intended for scholars in the field of organic chemistry, and researchers in industrial chemistry and chemical engineering departments. Key features: - Presents a comparison to homologous compounds of other alkaline earth metals. - Explains the main problems encountered in the synthesis of organocalcium compounds with reference to the reactivity of calcium, the low solubility in common solvents and the high reactivity of the formed intermediates and products - Highlights many concepts about the Ca-C bond such as the steric hindrance, degrading agent properties, organocalcium spectroscopy, and more

This reference provides collective information about the physical and photophysical changes of supramolecules after encapsulation. It covers luminescent systems involving a range of host molecules such as calixarenes, cyclodextrin, resorcinanene-crowns, pillararenes, cucurbituril, and metallacycles. Chapters also discuss the effect of the macrocyclic environment on the properties of functionalized molecules, including the variations in folding and unfolding patterns. Each chapter is supplemented with detailed references, making this an ideal resource for scholars interested in supramolecular photophysics.

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. The series presents comprehensive reviews written by eminent authorities on different synthetic approaches to selected target molecules and new methods developed to achieve specific synthetic transformations or optimal product yields. Advances in Organic Synthesis is essential for all organic chemists in academia and the industry who wish to keep abreast of rapid and important developments in the field. Contents of this volume include these 6 reviews: - Multicomponent synthesis of heterocycles by microwave irradiation - Stereoselective procedures for the synthesis of olefines - Advanced microwave assisted organic synthesis method in organic chemistry - Five and six-membered n-heterocycle rings from diaminomaleonitrile - Peptidomimetics: current and future perspectives on hiv protease inhibitors - A review on synthesis, chemistry, and medicinal properties of benzothiazines and their related scaffolds

This book provides an update on heterocyclic compounds that serve as key components of anti-cancer agents administered in pre-clinical settings. Many of the compounds highlighted in the book are being actively investigated for the bioactive properties against a range of cancer cell lines. There is potential for heterocyclic compounds to design agents that can target specific molecules to treat different types of cancers. Chapters are contributed by experts in pharmaceutical chemistry and are written to give a general overview of the topic to readers involved in all levels of research and decision-making in pharmaceutical chemistry and anti-cancer drug design. Part 1 of the book set covers these topics: - Heterocyclic anticancer compounds derived from natural sources with their mechanism of action - The role of terpenoids as anticancer compounds: an insight into prevention and treatment - Recent advances in synthesis and anticancer activity of benzothiazole hybrids as anticancer agents - Structure-activity relationship studies of novel hybrid quinoline and quinolone derivatives as anticancer agents - Tetrazoles: structure and activity relationship as anticancer agents - Progress in nitrogen and oxygen-based heterocyclic compounds for their anticancer activity: an update (2017-2020)

Frontiers in Natural Product Chemistry is a book series devoted to important advances in natural product chemistry. The series features volumes that cover all aspects of research in the chemistry and biochemistry of naturally occurring compounds, including research on natural substances derived from plants, microbes and animals. Reviews of structure elucidation, biological activity, organic and experimental synthesis of natural products as well as developments of new methods are also included in the series. Volume 10 of the series brings together 5 reviews on a variety of bioactive compounds. · An overview of cistus species growing in Sardinia: a source of bioactive compounds · Roles of natural abscisic acids in fruits during fruit development and under environmental stress · Progress in the research of naturally occurring biflavonoids: a look through · Plant metabolites for protecting human cells against radiation-associated damage: an integrative review · Chemical perspective and drawbacks in flavonoid estimation assays

This textbook summarizes preliminary knowledge of bioactive molecules which serve as pharmaceuticals, their use, synthesis and mode of action, as well as the production of commercial constituents such as ethanol, citric acid, antibiotics, amino acid, and vitamins. The text is written mainly for the undergraduate and graduate levels of study of all Indian universities according to the recently implemented CBCS curriculum in a simple manner while keeping postgraduate course structures in view. Key Features: Simple structured layout suitable for learners - Considers the CBCS curriculum for Indian Institutions - Covers the subject in 2 parts (Part A: Pharmaceutical Chemistry, Part B: Production) - Covers several types of pharmaceuticals used in clinical practice - Covers the fermentation process and the production of antibiotics, pharmaceutical commodities, and nutrients - Includes an appendix for handy information

This book details all the intricacies and essential knowledge involved in the research and development of the Coronil Kit - a combination of 3 ayurvedic medications for the common cold. It informs the reader about the huge potential of herbal drugs in fighting against any type of disease through evidence-based data from clinical trials and experiments. The book elaborates how current scientific techniques can be applied to understand the healing capacities of plants at their molecular level and thus utilize their different combinations to treat diseases by targeting harmful micro-organisms and simultaneously boosting the immune system. It covers methods of virtual screening and computational validation of identified phytochemicals as potential antiviral agents against the SARS-CoV-2 virus. 70 colored figures. Key Features: 1. Covers the molecular etiology of COVID-19 virus, 2. Covers guidance on drug formulation, hazard assessment, and clinical trials based on approved methods by regulatory organizations 3. Covers pharmacological, toxicological, and technically verified chemical composition of medicinal plants 4. Includes information about in vivo experiments and analysis of Humanoid Zebrafish trials 5. Includes methods of identifying antiviral agents against the SARS-CoV-2 virus 6. Includes chemical, analytical and technical studies of Coronil 7. Includes 70 images 7 chapters 8. Includes a bibliography and appendix The book is primarily intended as a primary resource for medical research scholars and researchers in pharmaceutical companies and as a secondary resource for B.A.M.S. students, medical postgraduate students, and Ayurveda enthusiasts.

This reference summarizes information about pharmaceuticals that can target infectious strains of coronaviruses to neutralize infections. Chapters focus on SARS-CoV-2, drug discovery methods and natural methods to combat the virus, which is a causative agent of COVID-19. Specifically, the book presents 5 chapters written by expert scholar on the following topics: Structure-Based Drug Discovery Approaches Applied to SARS-CoV-2 (the causative agent COVID- 19) Potential Antiviral Medicinal Plants against Novel SARS-CoV-2 Infections Caused by SARS Coronaviruses: Main Characteristics, Targets and Inhibitors Natural Sourced Traditional Indian and Chinese Medicines to Combat COVID- 19 Peptidomimetic and Peptide-Derived Agents Against 3CLpro from Coronaviruses The book contents present both conventional drug design and traditional approaches to discovering relevant drugs in an easy-to-read approach, which is supplemented by bibliographic references. It is intended as a reference for students (pharmacology, pharmacy) and researchers (virology) who are seeking information about antiviral drugs that can be used against coronaviruses.

Chemistry of Bipyrazoles: Synthesis and Applications covers the synthetic pathways for all types of bipyrazoles. 5 chapters cover bipyrazole systems, N,N- and N,C-bipyrazoles, namely 1,1`-bipyrazole, 1,3`-bipyrazole, 1,4`-bipyrazole, 3,3`-bipyrazoles, 3,4`-bipyrazoles and 4,4`-bipyrazoles The contents explain several types of reactions: 1) condensation reactions of hydrazines with tetracarbonyls, dihydroxydicarbonyl compounds or pyrazole-based difunctional compounds; 2) 1,3-dipolar cycloaddition of pyrazole-based hydrazonoyl halides with activated methylene compounds; 3) metal catalyzed cross-coupling reactions. The book concludes with a chapter that details the applications of bipyrazole derivatives in different industries. Information about advanced concepts used in chemical engineering such as metal-organic frameworks (MOFs) and corrosion inhibition are highlighted. The book contents are presented in an easy-to-understand manner suitable for readers in organic chemistry at senior levels of education and industry expertise. Each chapter is supplemented with detailed references.

Frontiers in Cardiovascular Drug Discovery is a book series devoted to publishing the latest advances in cardiovascular drug design and discovery. Each volume brings reviews on the biochemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships of molecules used in cardiovascular therapy. The book series should prove to be of great interest to all medicinal chemists and pharmaceutical scientists involved in preclinical and clinical research in cardiology. Volume 6 covers the following topics: - Cardiovascular effects of ranolazine and the scope for translational research: a current review of literature - Rho/Rho kinase signaling pathway and disease: - Hibernation or transformation? Challenges in cardiovascular drug development - New approaches in P2Y12 receptor blocker drugs use - Pathophysiological links between diabetes and cardiovascular diseases: at the biochemical and molecular levels