Abstract
This chapter is brief review of solubility and related concepts, lipid-water partition coefficients and their significance in drug bioavailability. After study of this chapter, students will be able to: • Analyze and predict the solubility of drugs. • Identify factors affecting the solubility of drugs. • Project the polarity, hydrophilicity, hydrophobicity, lipophilicity of drugs and their influence on solubility. • Predict the water or lipid solubility of drugs from their structures. • Comprehend the concept of partition coefficient. • Apply the concept of lipid water partition coefficient (LWPC) and its significance in drug bioavailability and action.
Keywords: Hydrophobicity, Hydrophilicity, Lipid-water partition coefficient, Lipophilicity, Solubility, Water solubilizing potential.
About this chapter
Cite this chapter as:
Hardeep Singh Saluja, M. O. Faruk Khan ;Solubility and Lipid-Water Partition Coefficient, Medicinal Chemistry for Pharmacy Students Fundamentals of Medicinal Chemistry and Drug Metabolism (2018) 1: 109. https://doi.org/10.2174/9781681086873118010007
DOI https://doi.org/10.2174/9781681086873118010007 |
Print ISSN 2589-6997 |
Publisher Name Bentham Science Publisher |
Online ISSN 2589-6989 |